Excretion of conjugated 2-amino-3-hydroxyacetophenone by man, and its significance in tryptophan metabolism
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چکیده
منابع مشابه
Excretion of conjugated 2-amino-3-hydroxyacetophenone by man, and its significance in tryptophan metabolism.
nine is excreted on giving tryptophan to rats with a simple thiamine deficiency. 3. It is therefore concluded that thiamine is concerned in the conversion of tryptophan into formylkynurenine. 4. Similar experiments combining biotin and pyridoxine deficiencies suggest that biotin is unlikely to be concerned in any stage in the conversion of tryptophan into hydroxykynurenine. 5. Considerable adva...
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The amino acid tryptophan is unique because it contains the indole nucleus and because it is metabolized in man through several different biochemical pathways to a number of specific products. It is the precursor of serotonin and 5-hydroxyindoleacetic acid. In addition, after cleavage of the indole ring, it may be metabolized by way of the kynurenine pathway to 3-hydroxyanthranilic acid and ult...
متن کاملTryptophan Metabolism in Man * ALFRED
The amino acid tryptophan is unique because it contains the indole nucleus and because it is metabolized in man through several different biochemical pathways to a number of specific products. It is the precursor of serotonin and 5-hydroxyindoleacetic acid. In addition, after cleavage of the indole ring, it may be metabolized by way of the kynurenine pathway to 3-hydroxyanthranilic acid and ult...
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In 1946, Rosen e2 al. (1) showed that administration of tryptophan to rats resulted in an additional excretion of nicotinic acid and Nl-methylnicotinamide (Nl-Me). Singal et al. (2) found, in addition to these, increased excretion of another metabolite which could be converted to nicotinic acid by autoclaving in 1 N sulfuric acid solution. Henderson isolated this metabolite from the urine of ra...
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Chenodeoxycholyl-2,4-(3)H-glycine-1-(14)C and deoxycholyl-2,4-(3)H-glycine-1-(14)C were synthesized and administered orally to 10 healthy subjects. Distribution of radioactivity among bile acids and specific activity of steroid and amino acid moieties were determined in bile samples. (3)H and (14)C were measured in feces. (14)C in breath was calculated from interval (14)CO(2) specific activity ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1955
ISSN: 0306-3283
DOI: 10.1042/bj0610334